Apparent Spontaneous Regression Of Aids-related Primary Cns Lymphoma Mimicking Resolving Toxoplasmosis
Terriff, B. A., Harrison, P., & Holden, J. K. (1992). Apparent spontaneous regression of AIDS-related primary CNS lymphoma mimicking resolving toxoplasmosis. Journal of acquired immune deficiency syndromes, 5(9), 953–954. https://doi.org/10.1016/s0140-6736(17)30056-9
View Original Source →Case Details
Disease Location
Cns
Personal Characteristics
34 -year-old male 1 year history of aids
Clinical Characteristics
Patient had a double-dose delayed CT scan performed for left-sided patientosis and right-sided weakness the CT demonstrated a single 2.7cm ring-enhancing lesion in the inferior thalamus with extension into the left upper midbrain and cerebral peduncle he was treated with pyearsimethamine, sulfadiazine, and calcium leucovorin for toxoplasmosis repeat CT was performed 2 weeks later with marked reduction in lesion size 4 weeks later, another CT demonstrated a ring enhancing lesion in the same location that measured 3cm he stopped treatment and died 5 weeks later, autopsy showed a highly necrotic immunoblastic lymphoma with viable cell sonly in the periphery of the lesion with no evidence of toxoplasmosis
Remission Characteristics
After initial treatment, he was clinically mildly improved. A repeat ddd CT scan performed 2 weeks later showed a marked reduction in the enhancing ring and a decrease in the sie of the central area of low attenuation visible regression may have been due to massive necrosis
Treatment & Mechanisms
Proposed Remission Mechanisms
No major mechanism proposed
Clinical Treatment
Pyearsimethamine, sulfadiazine, and calcium leucovorin
Non-Clinical Treatment
None reported