A Case Of Spontaneous Regression Of Advanced Colon Cancer.
Shimizu, H., Kochi, M., Kaiga, T., Mihara, Y., Fujii, M., & Takayama, T. (2010). A case of spontaneous regression of advanced colon cancer. Anticancer research, 30(6), 2351–2353.
View Original Source →Abstract
A case of spontaneous regression of colon cancer is reported. The patient, an 80-year-old man, was referred to hospital in January 2004. Colonoscopy revealed a type 2 tumour in the transverse colon which was diagnosed as an adenocarcinoma. A computed tomography scan also revealed a right renal tumour. Urological examination disclosed renal cell cancer. The patient subsequently refused surgical treatment and did not visit the hospital again for 6 months, during which time he received neither anticancer treatment nor any other medication. Another colonoscopy in August 2004 resulted in reclassification of the tumour to a IIc lesion, and the biopsy was negative for cancer. A right nephrectomy was carried out, and observation was performed for development of colonic lesions. In January 2007, colonoscopy revealed that the IIc lesion had disappeared. The patient was still alive with no sign of recurrence 64 months after disappearance of the lesion. CONCLUSION: This finding suggests that spontaneous regression can occur in advanced colon cancer.
Case Details
Disease Location
Transverse colon
Personal Characteristics
80-year-old man with hypertension
Clinical Characteristics
The patient complained of lower abdominal pain and tarry stool. A barium enema examination and colonoscopy disclosed a borrmann type ii tumour in the transverse colon measuring 2.5 cm × 2.5 cm. Biopsy specimens from the tumour demonstrated moderately differentiated adenocarcinoma.a computed tomographic scan also revealed a right renal tumour and renal hydronephrosis, with no evidence of liver or lymph node metastases. A urological examination was carried out resulting in a diagnosis of double primary colon and renal cell cancer.
Remission Characteristics
6 months later, a preoperative colonoscopy resulted in the tumour being reclassified to a iic lesion, with disappearance of transverse colon cancer. A biopsy was performed at the location of the earlier lesion and the result was negative for cancer.
Treatment & Mechanisms
Proposed Remission Mechanisms
Tumour dislodgement by some kind of physical stimulation such as peristaltic movement due to a laxative or the effect of some type of medical examination such as barium enema or colonoscopy
Clinical Treatment
Right nefrectomy for renal cell carcinoma.
Additional Notes
Kidney ca was mentioned but not the focus of the case