Protracted Benet From Paradoxical Kinesia In Typical And Atypical Parkinsonisms
Bonanni, L., Thomas, A., Anzellotti, F., monthsaco, D., Ciccocioppo, F., Varanese, S., Bifolchetti, S., D'Amico, M. C., Di Iorio, A., & Onofrj, M. (2010). Protracted benefit from paradoxical kinesia in typical and atypical parkinsonisms. Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, 31(6), 751–756. https://doi.org/10.1007/s10072-010-0403-5
View Original Source →Case Details
Disease Location
Basal ganglia
Personal Characteristics
59 -year-old male retired chemical engineer,
Clinical Characteristics
Diagnosed with ipd 10 years before quake, motor fluctuations appeared 6 years after initial diagnosis and were seen 3 months before the quake in afternoon off periods and peak-dose dyskinesias. Updrs motor score was 36, dyskinesia score was 3, freezing score of 4, fog-q of 22.
Remission Characteristics
Treatment continued, 2 months after quake updrs motor score was 21, freezing was less frequent, fog-q was 6, mmse was 21, dyskinesias improved, and a updrs went from 3 to 2. 5 months after quake, updrs motor score worsened to 38, freezing went to a 4, and fog-q went to 20
Treatment & Mechanisms
Proposed Remission Mechanisms
Noradrenergic augmentation (effect of a life threatening event)/different noradrenergic responses to stress compensatory activation of cerebellar circuitry activation of basal ganglia reserves pk may occur in patients with core and supportive elements typical of ipd-d or dlb
Clinical Treatment
3 months before quake was treated with l-dopa 400mg/day, ropinirole prolonged-release 16mg/day, amantadine 300mg/day, rasagiline 1mg/day and prolong-release l-dopa 200mg/day at night for nocturnal akinesia
Non-Clinical Treatment
Earthquake (life-threatening event)