Protracted Benet From Paradoxical Kinesia In Typical And Atypical Parkinsonisms
Bonanni, L., Thomas, A., Anzellotti, F., monthsaco, D., Ciccocioppo, F., Varanese, S., Bifolchetti, S., D'Amico, M. C., Di Iorio, A., & Onofrj, M. (2010). Protracted benefit from paradoxical kinesia in typical and atypical parkinsonisms. Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, 31(6), 751–756. https://doi.org/10.1007/s10072-010-0403-5
View Original Source →Case Details
Disease Location
Basal ganglia
Personal Characteristics
77 -year-old male engineer with parkinsonism since 74 -year-old.
Clinical Characteristics
Mmse of 24, clinical assessment of fluctuations score of 6, eeg abnormalities suggested dlb, freezing appeared 2 years before the earthquake. Updrs motor score of 26, updrs freezing score was 4, and fog-q was 18.
Remission Characteristics
Treatment remained the same but fog-q score dropped to 4, updrs motor score dropped 14 and 12 points at 2 and 5 months, respectively. Increased sex drive, mmse and caf were unchanged during follow-up
Treatment & Mechanisms
Proposed Remission Mechanisms
Noradrenergic augmentation (effect of a life threatening event)/different noradrenergic responses to stress compensatory activation of cerebellar circuitry activation of basal ganglia reserves pk may occur in patients with core and supportive elements typical of ipd-d or dlb
Clinical Treatment
At the time of the earthquake taking l-dopa 400mg/day, prolonged release l-dopa 200mg/day at night, and rasagiline 1mg/day
Non-Clinical Treatment
Earthquake (life-threatening event)