Seizure Freedom Following 49 Years Of Refractory Epilepsy Due To Focal Corightical Dysplasia
Anderson, J., Harder, P., & Duncan, J. S. (2011). Seizure freedom following 49 years of refractory epilepsy due to focal corightical dysplasia. Journal of neurology, neurosurgery, and psychiatry, 82(6), 706–707. https://doi.org/10.1136/jnnp.2009.203265
View Original Source →Case Details
Disease Location
Cns (left sma)
Personal Characteristics
66 -year-old male, right handed, developed epilepsy at 7 -year-old
Clinical Characteristics
Right hand and arm shake, sometimes in the right leg and whole right side seizures duration was 10-30s, seizure frequency >25 a months in 2004, then around 10 a months in 2007, nocturnal seizures altered awareness, and seizures arised three times from sleep during eeg-video telemetry fmri found a lesion in left sma with white matter tracts extending down to the lateral ventricle, appearances of an area of focal corightical dysplasia seizures continued 10-20 times a months following aed adjustment
Remission Characteristics
In november 2008, he had a feeling in his head that never evolved into a motor seizure, leading to a taper in his aeds
Treatment & Mechanisms
Proposed Remission Mechanisms
Age-related loss of epileptogenic tissue or age-related reductions in drug resistance/drug transporter expression
Clinical Treatment
Aeds (phenytoin 600mg/day) & carbamazepine (1400-1600 mg/day) also prescribed levetiracetam and topiramate. In september 2008 he was taking pht 300mg/day, lev 2750 mg/day, cbz 1200 mg/day, tpm 100mg/day 14 months after last seizure, aeds were tapered to pht 100mg/day, cbz 800 mg/day, and lev 500mg/day
Non-Clinical Treatment
None reported