Spontaneous Regression Of Pulmonary Metastases From Renal Cell Carcinoma After Radio Frequency Ablation Of Primary Tumor: An In Situ Tumor Vaccine?

Sanchez-Orightiz et al., 2003Kidney cancer

Sánchez-Orightiz, R. F., Tannir, N., Ahrar, K., & Wood, C. G. (2003). spontaneous regression of pulmonary metastases from renal cell carcinoma after radio frequency ablation of primary tumor: an in situ tumor vaccine?. The Journal of urology, 170(1), 178–179. https://doi.org/10.1097/01.ju.0000070823.38336.7b

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Abstract

No AccessJournal of UrologyCLINICAL UROLOGY: Case Reports1 Jul 2003Spontaneous Regression of Pulmonary Metastases From Renal Cell Carcinoma After Radio Frequency Ablation of Primary Tumor: In Situ Tumor Vaccine? RICARDO F. SÁNCHEZ-ORTIZ, NIZAR TANNIR, KAMRAN AHRAR, and CHRISTOPHER G. WOOD RICARDO F. SÁNCHEZ-ORTIZRICARDO F. SÁNCHEZ-ORTIZ , NIZAR TANNIRNIZAR TANNIR , KAMRAN AHRARKAMRAN AHRAR , and CHRISTOPHER G. WOODCHRISTOPHER G. WOOD View All Author Informationhttps://doi.org/10.1097/01.ju.0000070823.38336.7bAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail "Spontaneous Regression of Pulmonary Metastases From Renal Cell Carcinoma After Radio Frequency Ablation of Primary Tumor: In Situ Tumor Vaccine?." The Journal of Urology, 170(1), pp. 178–179 References 1 : The treatment of malignant tumors by repeated inoculations of erysipelas: with a report of ten original cases. Am J Med Sci1893; 105: 487. Google Scholar 2 : Immunologic changes in renal cell carcinoma patients receiving gamma interferon. Oncology1991; 48: 464. Google Scholar 3 : Fingerprinting the circulating repertoire of antibodies from cancer patients. Nat Biotechnol2003; 21: 57. Google Scholar From the Departments of Urology (RFS-O, CGW), Genitourinary Medical Oncology (NT) and Interventional Radiology (KA), University of Texas M.D. Anderson Cancer Center, Houston, Texas

Case Details

Disease Location

Kidney with lung mets

Personal Characteristics

56-year-old man

Clinical Characteristics

Painless gross hematuria. CT demonstrated a 5 cm enhancing left renal mass, for which the patient underwent radical nephrectomy. Pathological examination revealed a conventional type (clear cell) fuhrman grade ii rcc extending into the perinephric fat. 7 years later, when right flank pain and hematuria developed. Abdominal MRI showed a 6 cm irregular enhancing right upper pole renal mass without abdominal metastases or venous invasion. Chest CT demonstrated bilateral pulmonary metastases, 4 in the right lung (largest 18 mm) and a single 3 mm nodule in the left lung. Biopsy was compatible with metastatic conventional (clear cell) rcc consistent with the left renal tumor originally managed with nephrectomy.

Remission Characteristics

The patient was treated with rfa for the right kidney mass. Followup chest CT and abdominal MRI at 2, 5, 7 and 10 months after rfa revealed complete disappearance of the pulmonary metastases and lack of enhancement of the renal mass