Spontaneous Remission Of Immunotactoid Glomerulopathy
Rood, I. M., Lieverse, L. G., Steenbergen, E. J., Wetzels, J. F., & Deegens, J. K. (2011). spontaneous remission of immunotactoid glomerulopathy. The Netherlands journal of medicine, 69(7), 341–344. https://doi.org/10.32388/2uin10
View Original Source →Abstract
Immunotactoid glomerulopathy (ITG ) is a rare cause of nephrotic syndrome, occurring in approximately 0.1% of native kidney biopsies. We describe a 43-year-old woman who presented with a nephrotic syndrome. Renal biopsy revealed a membranous pattern of glomerular injury. In electron microscopy the subepithelial deposits were comprised of 40 nm wide tubular structures, confirming ITG . During follow-up the patient developed a remission of proteinuria with only supportive treatment.
Case Details
Disease Location
Kidney
Personal Characteristics
A 43-year-old woman, more than year history of relapsing-remitting multiple sclerosis.
Clinical Characteristics
Progressive tiredness, leg cramps, oedema and proteinuria. Pe: pitting oedema in the lower extremities. Laboratory studies showed hypoalbuminemia and proteinuria. Autoimmune active markers were negative. Renal biopsy showed normal glomeruli with negative immunofluorescence. A diagnosis of minimal change disease was made. Ambulatory supportive therapy was initiated. 6 months after the discharge, a new renal biopsy showed findings compatible with a diagnosis of itg
Remission Characteristics
During follow-up the serum creatinine remained stable, and proteinuria decreased
Treatment & Mechanisms
Proposed Remission Mechanisms
Not discussed
Clinical Treatment
Intravenous methylpred- nisolone. (for ms) interferon (for ms - discontinued 2 years before presentation). Loop diuretic, an ace inhibitor and a statin