spontaneous Remission of Metastases of Cancer of the Uterine Cervix

Abstract

SR is a rare but evident phenomenon. Individual features of malignant tumors should be taken into account much more when determining the best treatment for the patient.

Case Details

Disease Location

Uterine cervix

Personal Characteristics

36 -year-old female 13th week of her first pregnancy

Clinical Characteristics

Admitted september 1994 with histologically proven carcinoma of the uterine cervix an operation to remove the cervix, pregnant uterus and parametrial tissue was carried out tissue from the suspicious vulvar epithelium was also removed histology showed a pregnant uterus with an undifferentiated squamous cell carcinoma of the cervix classified as figo stage i with carcinomatous lymphangitis (patient1b g3 pn0) as well as carcinoma in situ of the nulvar epithelium in march 1995, after biopsies, laser vaporization of the vulvar skin was performed, histology revealed severe dysplasia without carcinoma may 1995, patient re-admitted with severe dyspnea, chest xrays and CT found multiple intrapulmonary tumors and abnormal mediastinal lymph nodes, the pleura showed a tumor located on the left side, biospy of that site confirmed a carcinoma consisting of relatively small cells, not resembling those of bronchial carcinoma skin on the left side of the back showed a firm and painful tumor which was removed, histology was consistent with previous findings non-suspicious ovarian mass was found isotope bone scan showed track accumulation in the thoracic and lumbar spine and right femur abdominal ctshowed osteolytic metastases in the 11th vertebral body of the thoracic spine and second body of the lumbar palliative chemo with cisplatin was administered, but was abandoned chest xray in april 1997 showed neither intrapulmonary tumors nor pleural thickening but in september 1997, she was symptomatic again with gait disturbances MRI revealed a tumor in the left parieto-occipital region, which was removed incompletely and histologically revealed metastases of the previously diagnoses cervical carcinoma after surgery, she recieved brain radiotherapy 5 times a week may 2004, growth on ovary showed low continuous growth and was removed as well as the ovaries and fallopian tubes, histology showed a benign ovarian cyst 2003, all histological specimens were re-examined and the diagnosis of a partly small-cell and partly large-cell carcinoma of the uterine cervix (g3) with metastasis to the brain, skin and pleura was confirmed using ihc

Remission Characteristics

From january 1998 - january 2004, follow up exams were uneventful ( xray, CT of brain, chest, abdomen, bone scan and gynecologic exam) a further chest CT showed no evidence of the previously diagnosed large pleural tumor bone scans showed remission of tumor activity CT confirmed recalcification of the bone metastases after a 10 year observation period, she fulfils the criteria for sr

Treatment & Mechanisms

Proposed Remission Mechanisms

No specific proposed mechanism for this case immunomodulation is mentioned

Clinical Treatment

Organ removal, biopsies, laser vaporization, chemo, radiotherapy

Non-Clinical Treatment

None reported