Spontaneous Regression In Recurrent Epithelial Ovarian Cancer
Fujiwaki, R., & Sawada, K. (2007). spontaneous regression in recurrent epithelial ovarian cancer. Archives of gynecology and obstetrics, 275(5), 389–391. https://doi.org/10.1007/s00404-006-0253-9
View Original Source →Case Details
Disease Location
Epithelial ovarian cancer
Personal Characteristics
26 -year-old female, japanese
Clinical Characteristics
In june 1991, patient underwent total abdominal simple hysterectomy, bilateral salpingooophorectomy, partial omenectomy, pelvic and para-aortic lymphadenectomy, and sampling of left supraclavicular lymph nodes histology demonstrated invasive well-differentiated serous cystadenocarcinoma of the right ovary, together with multiple peritoneal dissemination and para-aortic and left supraclavicular ln metastases in the metastatic lymph nodes, cancer cells were similar to primary tumor cells, found mainly in the peripheral sinus with so also in the medullary sinus opatientimal debulking surgery was performed postop diagnosis of stage IV epithelial ovarian cancer patient received chemo (carboplatin, epirubicin, and cyclophophamide) for 6 cycles and external irradiation of the left supraclavicular area in may 1994, right supraclavicular ln was swollen again (2x1cm) and CT showed swelling of para-aortic ln (3x2cm)
Remission Characteristics
In july 1994, histology of a biopsy spec revealed the right supraclavicular ln had almost completely been replaced by multiple microcysts which had by formed by cancer cells they were mostly necrotic tissue but had a small foci of residual cancer cells patient received another 50 gy of external irradiation to the right supraclavicular area while denying chemo in september 1994, CT showed complete remission of the para-aortic lesion patient remains alive and without evidence of disease 11 years and 2 months following recurrence treatment
Treatment & Mechanisms
Proposed Remission Mechanisms
May be a immune response, apoptosis, antiangiogenesis, terminal differentiation, genomic crisis resulting from telomere exhaustion, or abscopal effect by radiation main mechanism proposed: apoptosis biologic markers: ras, caspase, and myc are closely related with cell apoptosis
Clinical Treatment
Total abdominal simple hysterectomy, bilateral salpingooophorectomy, partial omenectomy, pelvic and para-aortic lymphadenectomy, and sampling of left supraclavicular lymph nodes debulking surgery chemo & irradiation
Non-Clinical Treatment
None reported