Ebv Associated Hemophagocytic Lymphohistiocytosis With Spontaneous Regression
Bakhshi, S., & Pautu, J. L. (2005). EBV associated hemophagocytic lymphohistiocytosis with spontaneous regression. Indian pediatrics, 42(12), 1253–1255.
View Original Source →Case Details
Disease Location
Blood
Personal Characteristics
9 years old boy, previously healthy
Clinical Characteristics
10 days of fever, weakness, epistaxis and purpura. Marked pallor, petechiae over limbs and trunk, 1- 1.5 cm multiple sub-mental lymph nodes, 3 cm hepatomegaly and 5 cm splenomegaly below costal margins. Pancytopenia with lymphocytosis; elevated alt and ast. Bone marrow aspiration (bma) revealed dyserythropoiesis and several histiocytes, some of which were exhibiting erythrophagocytosis suggestive of hemophagocytic lymphohistiocytosis (hemophagocytic lymphohistiocytosis).. Elevated serum ldh, triglyceride and ferritin levels. Final diagnosis ebv associated hemophagocytic lymphohistiocytosis
Remission Characteristics
Within a week, patient was asymptomatic and follow-up showed gradual improvement with normalization of biochemical abnormalities and bma at 6 weeks.
Treatment & Mechanisms
Proposed Remission Mechanisms
Not discussed
Clinical Treatment
Supportive care including intra-venous antibiotics, platelet and blood transfusions.