Spontaneous Remission Of Agnogenic Myeloid Metaplasia And Termination In Acute Myeloid Leukemia
Archives of Internal Medicine 141(11): Oct 1981; 1481-1484
View Original Source →Case Details
Personal Characteristics
Two men
Clinical Characteristics
Acute myeloid leukemia developed in two men with well-documented agnogenic myeloid metaplasia 49 and 27 months, respectively, after initial diagnosis. Both men had spontaneous hematologic remissions of myeloid metaplasia 22 and 16 months prior to leukemic transformation.
Remission Characteristics
Spontaneous hematologic remissions of myeloid metaplasia 22 and 16 months prior to leukemic transformation
Treatment & Mechanisms
Proposed Remission Mechanisms
Not discussed
Clinical Treatment
Neither patient received any precedent radiation or cytotoxic chemotherapy.
Additional Notes
The remissions and subsequent transformation to acute leukemia were documented by bone marrow aspiration, biopsy, and reticuloendothelial marrow scans, as well as in-vitro cell cultures and cytogenetic study. A review of the literature revealed nine other patients who had conversion to acute leukemia in the absence of preceding radiation or cytotoxic chemotherapy. However, the present report seems to be the first describing spontaneous hematologic remission prior to transformation to leukemia.