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Lupus Anticoagulant And Acquired Prothrombin Deficiency During Viral Disease In A Child; Spontaneous Recovery

Houbouyan et al., 1984Lymphoma

Archives Francaises de Pediatrie 41(6): Jun-Jul 1984; 417-420

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Abstract

This is the first known report of a case of angio-immunoblastic lymphadenopathy, with dysproteinemia (AILD) in childhood which evolved toward a spontaneous remission. The disease had an acute onset with generalized lymphadenopathy, hepatosplenomegaly, high-grade fever and polyclonal hypergammaglobulinemia. The lymph nodes met all of the histologic criteria required for diagnosis as established by Frizzera et al. It is emphasized that AILD should be taken into consideration in the differential diagnosis of lymphadenopathy in childhood.

Case Details

Personal Characteristics

A 2-year-old female

Clinical Characteristics

Developed an acute bleeding diathesis related to a profound, isolated and acquired prothrombin deficiency; evidence for a lupus anticoagulant was also demonstrated

Remission Characteristics

Spontaneous and quick recovery

Treatment & Mechanisms

Proposed Remission Mechanisms

Not discussed

Additional Notes

This association of hypoprothrombinemia and lupus anticoagulant, rarely reported, was previously considered to be rather specific for SLE. This case report demonstrates that these coagulation disorders may present as an acute form, in viral diseases of the child. Specific characteristics of the biological coagulation defects, namely those related to the low factor II, are discussed.