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Spontaneous Remission In Myelodysplastic Syndrome; A Case Report

Broun et al., 1990Other/Unknown

Cancer Genetics and Cytogenetics 46(1): May 1990; 125-128. https://doi.org/10.1016/0165-4608(90)90018-6

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Abstract

A 2-year-old female developed an acute bleeding diathesis related to a profound, isolated and acquired prothrombin deficiency; evidence for a lupus anticoagulant was also demonstrated. This association of hypoprothrombinemia and lupus anticoagulant, rarely reported, was previously considered to be rather specific for SLE. This case report demonstrates that these coagulation disorders may present as an acute form, in viral diseases of the child, with spontaneous and quick recovery. Specific characteristics of the biological coagulation defects, namely those related to the low factor II, are discussed.

Case Details

Clinical Characteristics

Red blood cell (rbc) transfusion dependent, complex cytogenetic abnormality consisting of loss of chromosome 7 and trisomy 8

Remission Characteristics

Complete blood count (cbc) subsequently became normal, no longer transfusion dependent, repeat cytogenetic analyses are normal

Treatment & Mechanisms

Proposed Remission Mechanisms

Not discussed