Spontaneous Remission In Myelodysplastic Syndrome; A Case Report
Cancer Genetics and Cytogenetics 46(1): May 1990; 125-128. https://doi.org/10.1016/0165-4608(90)90018-6
View Original Source →Abstract
A 2-year-old female developed an acute bleeding diathesis related to a profound, isolated and acquired prothrombin deficiency; evidence for a lupus anticoagulant was also demonstrated. This association of hypoprothrombinemia and lupus anticoagulant, rarely reported, was previously considered to be rather specific for SLE. This case report demonstrates that these coagulation disorders may present as an acute form, in viral diseases of the child, with spontaneous and quick recovery. Specific characteristics of the biological coagulation defects, namely those related to the low factor II, are discussed.
Case Details
Clinical Characteristics
Red blood cell (rbc) transfusion dependent, complex cytogenetic abnormality consisting of loss of chromosome 7 and trisomy 8
Remission Characteristics
Complete blood count (cbc) subsequently became normal, no longer transfusion dependent, repeat cytogenetic analyses are normal
Treatment & Mechanisms
Proposed Remission Mechanisms
Not discussed