Spontaneous Recovery Of The Hemolytic Uremic Syndrome With Prolonged Renal And Neurological Manifestations
Nephron 32: 1982; 188-191
View Original Source →Abstract
A three-year-old girl who had for two months suffered bruising after minimal injury was admitted because of diffuse ecchymoses and a large haematoma hindering elbow movement. These symptoms were attributable to the development of antifactor VIII inhibitor. No definite etiology was evident despite repeated immunological investigation. Although the inhibitor still persisted at high levels after two years, no further haemorrhage occurred, excepted haematomas three months after the onset of symptoms, in association with mumps.
Case Details
Personal Characteristics
3-year-old girl
Clinical Characteristics
Severe hemolytic-uremic syndrome with oligoanuric for 31 days and coma for 35 days associated with cortical blindness
Remission Characteristics
Recovered both neurologic and renal function
Treatment & Mechanisms
Proposed Remission Mechanisms
Not discussed
Clinical Treatment
Peritoneal dialysis and supportive care only
Additional Notes
The spontaneous recovery of this patient, who had a particularly severe form of the hemolytic uremic syndrome, brings into question the necessity for the use of anticoagulation, antiplatelet agents, prostacyclin, and plasma exchange as treatments for the hemolytic-uremic syndrome.