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Spontaneous Regression Of A Cerebral Arteriovenous Malformation; Report Of A Case And Review Of The Literature

Wakai et al., 1983Other/Unknown

Archives of Neurology 40(6): June 1983; 377-380

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Abstract

Complete spontaneous resolution of an intracranial AVM without any antecedent history of direct surgical intervention is uncommon. A review of the available literature yielded only seven cases, most of them in single case reports. Although spontaneous resolution is acknowledged as a rare feature in the complex natural history of AVM, its true incidence is unknown. Causes or factors that predispose to spontaneous regression of AVMs remain poorly understood. The majority of the documented cases of spontaneous resolutions have occurred in small or medium sized supratentorial lesions supplied predominantly by one major feeder. We report herein the unique occurrence of complete spontaneous regression of a deep left temporal AVM in a 22- year-old right-handed man. This case typifies the common picture, a clinical presentation of intracranial hemorrhage with raised intracranial pressure followed by complete resolution of the lesion.

Case Details

Personal Characteristics

A 14-year-old boy

Clinical Characteristics

Experienced sudden severe headache, dizziness, and vomiting, neck stiffness, major motor seizures, severe headache, nausea, and vomiting, neck stiffness, bloody csf with normal pressure, right carotid angiogram disclosed an avm in the basal portion of the right frontal lobe

Remission Characteristics

Bilateral carotid and left vertebral angiograms the next day disclosed complete disappearance of the avm

Treatment & Mechanisms

Proposed Remission Mechanisms

Previous bleeding episode

Clinical Treatment

Lumbar puncture, right carotid angiogram, bilateral carotid and left vertebral angiograms, CT scan

Additional Notes

The patient requested reevaluation of the AVM to provide a basis for promising new therapy. He is now doing well. There has been no seizure for two years. He is taking 40 milligrams of phenobarbital sodium, 100 milligrams of phenytoin sodium and 200 milligrams of carbamazepine daily.