Spontaneous Healing Of Langerhans Cell Histiocytosis (histiocytosis-x)
European Journal of Pediatrics 148(1): Oct 1988; 32-33
View Original Source →Case Details
Personal Characteristics
A 3-month-old male infant, d. B., without past history
Clinical Characteristics
Presented with pallor, hepatomegaly (4.5 centimeters), splenomegaly (1.5 centimeters), anaemia (hb 6 gm/dl) and thrombocytopenia (16 x 109/l). Liver biopsy showed histiocytic infiltration. Hepatomegaly diminished after 6 months and a second liver biopsy showed decreased histiocytic infiltration. After 14 months, the hepatomegaly had disappeared completely and there were no more abnormal haematological or clinical findings.
Remission Characteristics
Hepatomegaly diminished after 6 months and disappeared completely after 14 months. No more abnormal haematological or clinical findings after 14 months.
Treatment & Mechanisms
Proposed Remission Mechanisms
Not discussed
Clinical Treatment
No treatment was given.
Additional Notes
The patients lymphocytes, co-cultured with neonatal lymphocytes, were positive for virus-like particles without reverse transcriptase activity. A second viral blood culture remained negative.