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Spontaneous Remission Of Cushing’s Disease

Hayslett & Cohn, 1967Other/Unknown

New England Journal of Medicine 276(17): April 27 1967; 968-970

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Abstract

The natural course of Cushing’s disease has been obscured by the difficulties of diagnosis of the milder forms and the relative infrequency of the disorder. The case confirms earlier clinical observations that spontaneous remission may occur. Although most patients with Cushing’s disease require surgical or radiologic intervention, continued observation may be preferable in a case, like the one reported, with mild clinical disease and without evidence of osteoporosis, diabetes mellitus and other complicating features.

Case Details

Clinical Characteristics

Mild clinical disease and without evidence of osteoporosis, diabetes mellitus and other complicating features

Remission Characteristics

Spontaneous remission

Treatment & Mechanisms

Proposed Remission Mechanisms

Not discussed

Clinical Treatment

Surgical or radiologic intervention

Non-Clinical Treatment

Continued observation

Additional Notes

The natural course of Cushing’s disease has been obscured by the difficulties of diagnosis of the milder forms and the relative infrequency of the disorder. The case confirms earlier clinical observations that spontaneous remission may occur.