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Spontaneous Remission In Diabetes

Journal of the American Medical Association 196(12): June 20 1966; 1085

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Abstract

Diabetes is rarely thought of as a remitting disorder. In the June Archives of Internal Medicine, O’Sullivan and Hurwitz suggest that this view may have to be modified. Having studied sequential glucose tolerance tests in 83 nonpregnant young diabetic women six months to two years after the onset of the disease, these investigators found an improvement in 54% and a return to normal in 28%. This would suggest that a reassessment of therapy and diagnostic screening is necessary. What causes diabetes to submerge? O’Sullivan and Hurwitz, having found no apparent cause for the remissions, have designated them as “spontaneous.”

Case Details

Personal Characteristics

83 nonpregnant young diabetic women six months to two years after the onset of the disease

Clinical Characteristics

Sequential glucose tolerance tests

Remission Characteristics

Improvement in 54% and a return to normal in 28%

Treatment & Mechanisms

Proposed Remission Mechanisms

No apparent cause for the remissions, designated as spontaneous

Additional Notes

A reassessment of therapy and diagnostic screening is necessary