Recovery Of Thyroid Function With A Decreased Titre Of Antimicrosomal Antibody In A Hypothyroid Man With Hashimotos Thyroiditis
Acta Endocrinologica 102: 1983; 531-534
View Original Source →Abstract
A 36-year-old man with diffuse goitre, signs of mild hypothyroidism, strikingly low levels of T-4 (0.9 micrograms/dl) and T3 (24 nanograms/dl), elevated TSH (140 microU/ml) and elevated microsomal haemagglutination antibody (MCHA, 1:409,600), subsequently became nongoitrous and euthyroid with a decreased titre of antimicrosomal antibody without any medication. At the time of surgical biopsy, serum levels of T4 and T3 had risen to the normal range (4.6 micrograms/dl and 73 nanograms/dl, respectively), serum TSH had decreased to 30 microU/ ml and the titre of MCHA to 1:25,600. Thyroid specimens showed Hashimoto’s thyroiditis. The activity of thyroid peroxidase (TPO) was normal. The latest examination, 1 year and 3 months after initial evaluation, showed that the patient remained euthyroid with no goitre, that serum thyroid hormones were within the normal range (T4 7.7 micrograms/dl and T3 97 nanograms/dl), and that TSH was not detectable. The titre of MCHA decreased strikingly to 1:400.
Case Details
Personal Characteristics
A 36-year-old man with diffuse goitre, signs of mild hypothyroidism, strikingly low levels of t-4 (0.9 micrograms/dl) and t3 (24 nanograms/dl), elevated tsh (140 microu/ml) and elevated microsomal haemagglutination antibody (mcha, 1:409,600)
Clinical Characteristics
Swelling at the front of the neck, hoarseness and oedema of the face, slightly enlarged thyroid gland was diffuse, symmetrical and firm
Remission Characteristics
Became nongoitrous and euthyroid with a decreased titre of antimicrosomal antibody without any medication
Treatment & Mechanisms
Proposed Remission Mechanisms
Not discussed
Clinical Treatment
L-thyroxine (125 micrograms/day)
Additional Notes
Two of his relatives had Graves disease. At the time of surgical biopsy, serum levels of T4 and T3 had risen to the normal range (4.6 micrograms/dl and 73 nanograms/dl, respectively), serum TSH had decreased to 30 microU/ ml and the titre of MCHA to 1:25,600. Thyroid specimens showed Hashimotos thyroiditis. The activity of thyroid peroxidase (TPO) was normal. The latest examination, 1 year and 3 months after initial evaluation, showed that the patient remained euthyroid with no goitre, that serum thyroid hormones were within the normal range (T4 7.7 micrograms/dl and T3 97 nanograms/dl), and that TSH was not detectable. The titre of MCHA decreased strikingly to 1:400.