The Phenomenon Of Spontaneous Regression Of Numerous Flat Warts: Immunohistological Studies

Additional Notes

In other types of warts, we have never observed such a dramatic regression. We performed a histological study in a total of 51 cases showing this spontaneous inflammation in their flat warts and found a massive mononuclear cell infiltration in all. In 9 cases, a histological study for basophils was carried out but failed to show them among the infiltrating cells despite the strong histological resemblance to contact allergy. An immunofluorescence technique performed in 16 cases demonstrated no specific deposits of immunoglobulins and complement in such inflamed wart tissues except for those which appear to be only a secondary event to inflammation per se.