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Spontaneous Regression Of Non-hodgkin’s Lymphoma; A Report Of Nine Cases

Krikorian et al., 1980Lymphoma

Cancer 46(9): Nov 1 1980; 2093-2099

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Abstract

A case of spontaneous remission in a Stage IIA diffuse large-cell lymphoma is presented. A review of the literature suggests that whereas spontaneous regressions are a well-recognized phenomenon in indolent lymphomas, it is extremely rare in lymphomas of aggressive histologic subtype.

Case Details

Personal Characteristics

42-year-old man

Clinical Characteristics

Lymphadenopathy measuring up to 2 centimeters, asymptomatic

Remission Characteristics

Two months following his lymphogram, peripheral lymphadenopathy was noted to regress. Four months following his lymphogram he had no evidence of disease on physical examination and the previously abnormal lymph nodes observed on the abdominal lymphogram and chest roentgenogram had regressed showing equivocal abnormalities but no definite evidence of lymphoma.

Treatment & Mechanisms

Proposed Remission Mechanisms

Not discussed

Clinical Treatment

Observed without therapy

Additional Notes

He has continued asymptomatic and without evidence of disease five years since his initial diagnosis.