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Spontaneous Regression Of Hematologic Cancers

Wiernik, P. H. 1976Leukemia

National Cancer Institute Monographs 44: 1976; 35-38

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Abstract

Spontaneous regression of hematologic cancer is extremely rare. Data gleaned from the literature and from previously unreported cases allow certain interesting general conclusions. Spontaneous remission of acute leukemia is associated with bacterial infection and is of short duration, weeks to months. Spontaneous regression of lymphoma or plasma cell dyscrasia is often of substantial duration, months or years, and frequently is associated with viral infections. Spontaneous regression of chronic lymphocytic leukemia is also of significant duration and has been associated with the occurrence of a new primary carcinoma in one-third of the cases.

Case Details

Clinical Characteristics

Spontaneous regression of hematologic cancer is extremely rare. Spontaneous remission of acute leukemia is associated with bacterial infection and is of short duration, weeks to months. Spontaneous regression of lymphoma or plasma cell dyscrasia is often of substantial duration, months or years, and frequently is associated with viral infections. Spontaneous regression of chronic lymphocytic leukemia is also of significant duration and has been associated with the occurrence of a new primary carcinoma in one-third of the cases.

Remission Characteristics

Short duration for acute leukemia, substantial duration for lymphoma or plasma cell dyscrasia, significant duration for chronic lymphocytic leukemia

Treatment & Mechanisms

Proposed Remission Mechanisms

Acute leukemia is associated with bacterial infection, lymphoma or plasma cell dyscrasia is associated with viral infections, chronic lymphocytic leukemia is associated with the occurrence of a new primary carcinoma