Spontaneously Regressing Adrenocortical Carcinoma In A Newborn; A Case Report With Dna Ploidy Analysis
Cancer 62(3): Aug 1 1988; 507-511. https://doi.org/10.1002/1097-0142(19880801)62:3<507::aid-cncr2820620311>3.0.co;2-8
View Original Source →Abstract
Two women evaluated for amenorrhea, galactorrhea, and hyperprolactinemia had radiographic changes of the sella turcica (localized erosion on trispiral tomography) suggestive of a pituitary tumor. Both patients experienced spontaneous regression of apparent prolactin-secreting adenomas with a marked decrease in the quantity of galactorrhea and a reduction of serum prolactin concentrations to the normal range. One patient noted a marked improvement of headaches and spontaneous menses resumed in the other patient.
Case Details
Personal Characteristics
Newborn
Clinical Characteristics
Metastatic adrenal cortical carcinoma (skin metastases and cerebral lesions), hemihypertrophy developed by 2 months of age
Remission Characteristics
Spontaneous regression of all skin nodules and central nervous system (cns) lesions at 4 months of age
Treatment & Mechanisms
Proposed Remission Mechanisms
DNA ploidy analysis that showed the tumor to be polyploid, a pattern recently associated with nonmetastasizing adrenal cortical neoplasm
Clinical Treatment
Surgical resection of the right adrenal primary
Additional Notes
Follow-up at 1 year shows the patient to be alive, well, and disease-free. The observation of apparent metastatic disease that regressed spontaneously highlights the prognostic value of DNA ploidy analysis and raises the possibility of an adrenal tumor with properties similar to those of Stage IV-S neuroblastoma.