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Papillary Cystadenocarcinoma Of Both Ovaries; Report Of A Case With Apparent Cure Eight Years After Operation

Gaudrault, G. L. 1948Ovarian cancer

New England Journal of Medicine 239(2): Jul 8 1948; 56-57

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Abstract

A case of primary testicular malignant tumour with metastases of unusual distribution and behaviour is presented. Spontaneous retrogression of cervical and pulmonary metastases has occurred. This case has several interesting features. First, the presentation of the metastatic lymph nodes high up in the right suboccipital region and in the left supraclavicular fossa about seven months after a simple orchidectomy and abdominal irradiation of the relevant lymphatic fields is unusual. Second, in spite of the dispersal of tumour cells in the process of dissection and excision of the suboccipital node, the wound healed per primum and the residual disease here, as well as in the left supraclavicular fossa, disappeared spontaneously without any further treatment. Third, the pulmonary metastases which were so clearly evident on the chest x-ray film of March 28, 1962, were found to disappear spontaneously within the next few months and were no longer evident on films taken on September 10, 1963, and November 22, 1965. Fourth, a small intestinal metastasis presenting clinically as acute intestinal obstruction is very rare. Spontaneous arrest or retrogression of some cancers is now generally accepted, though the factors responsible are largely unknown. It seems certain that the cervical and pulmonary metastases have disappeared in the present case.

Case Details

Personal Characteristics

26-year-old housewife, a. S., married, no pregnancies

Clinical Characteristics

Discomfort in the lower abdomen, distention, menstrual irregularity, loss of weight, pain in the lumbar region and legs, pale and cachectic, abdomen distended and tender, small uterus in normal position, not movable, tender, diffuse mass in the pelvis, severe abdominal distress and distention, no bowel evacuation for 2 days, very little flatus, weight about 80 pounds

Remission Characteristics

After more than eight years she feels well, works every day, and is apparently cured

Treatment & Mechanisms

Proposed Remission Mechanisms

Not discussed

Clinical Treatment

Surgical treatment, laparotomy, biopsy, second operation to explore and insert a mushroom catheter, removal of papillary growths, two 500 cc transfusions

Non-Clinical Treatment

X-ray therapy

Additional Notes

The patient was treated as a hopeless case. She was tapped 63 times and from 5,000 to 10,000 cc of fluid removed every 2 or 3 weeks. She was kept comfortable with morphine, the dosage being increased to 30 milligrams every 3 hours. The patient was deprived of morphine after the second operation. The patient has been checked regularly every 6 months. She had one scant menstrual period and occasional hot flashes after the second operation.