Chorioadenoma Destruens of Uterus Spontaneous Regression of Pulmonary and Pelvic Metastases: A Case Report

Abstract

A woman with extensive ovarian papillary cystadenocarcinoma in the pelvis underwent bilateral ovarectomy two and a half years after the diagnosis had been established. A proved, persistent, untreated metastasis was resected seven years and nine months later. She was well ten years thereafter and twenty years and eight months from the time of original diagnosis.

Case Details

Personal Characteristics

A married, white female, age 28

Clinical Characteristics

Pain in the left lower side, bleeding from the cervix, uterus seemed enlarged to the size of a 5 or 6 weeks pregnancy, left adnexa were somewhat tender, positive frog test for pregnancy, continued bleeding, rapid growth of a hydatidiform mole, fever up to 103°f, high fever for several days, low backache and pain in the left lower quadrant and down the inner aspect of her left leg, tender mass in the left adnexa, abnormal density in the lungs highly indicative of metastatic disease

Remission Characteristics

Patient has had 18 months follow-up, has gained weight and returned to work and is apparently free of any disease at the present time

Treatment & Mechanisms

Proposed Remission Mechanisms

Not discussed

Clinical Treatment

Evacuation of the uterus, hysterectomy and bilateral salpingo-oophorectomy, surgery, transfusions

Non-Clinical Treatment

Ascorbic acid 100 milligrams twice a day and diethylstilbestrol 5 milligrams twice a day, antibiotics

Additional Notes

This case represents a chorioadenoma destruens of the uterus and pelvis following hydatidiform mole. A period of 3 months elapsed from the time of the evacuation of the mole from the uterus until the time of hysterectomy and bilateral salpingo-oophorectomy. Preoperative febrile course is impressive. This case further demonstrated by films the metastatic spread of this lesion to the lungs with spontaneous regression. It is noted that the primary treatment here was surgery with no chemical or x-ray therapy to the pelvis or to the pulmonary lesions.