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Angiography In Spontaneously Healed Hypernephromas

Bartley & Helander, 1962Kidney cancer

Acta Radiologica 57: 1962; 417-426

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Abstract

It is well documented that clear-cell carcinomas of the kidney (hypernephromas) regress under certain circumstances. Bartley and Hultquist clearly illustrated this when they reviewed the literature and reported 26 of their own cases in 1950. It is also known that, in some instances, distant metastases of clear-cell carcinomas of the kidney have been known to regress or disappear. Most reported regressions have been pulmonary metastases where the diagnosis was presumptive and where microscopic study of the pulmonary lesion was not available. In most cases, the regression occurred after removal of the primary lesion. What factors govern this type of response? No one knows for sure, but since many of the regressions have followed removal of the primary tumor, there is some suggestion that it may represent a response on the part of the body after removal of the primary mass. This could be on an immunologic basis or could represent hormonal control. The true incidence of regression of hypernephroma is unknown, but it is likely that it is considerably greater than is reported.

Case Details

Personal Characteristics

Male, aged 73

Clinical Characteristics

Urography disclosed an expansive process, about 5 centimeters in diameter, in the lateral part of the middle of the right kidney. Aortography was carried out in order, if possible, to determine the nature of the lesion.

Remission Characteristics

Nephrectomy was performed and the large expansive process, which proved to be cystic, was punctured. Contrast medium was injected into the cystic formation which at subsequent roentgen examination presented appearances typical of a renal cyst.

Treatment & Mechanisms

Proposed Remission Mechanisms

Not discussed

Clinical Treatment

Nephrectomy

Additional Notes

Histologic examination revealed that the capsule of the large cyst consisted of cell-deficient collagenous connective tissue in which elastic fibrils were irregularly interspersed and that remnants of hypernephroma cells with marked regressive changes were present in a circumscribed area in that part of the cyst directed towards the kidney surface.