Neuroblastoma
Journal of Pediatrics 61: 1962; 456
View Original Source →Abstract
Seven children with pelvic neuroblastoma between the ages of 2 weeks and one year eleven months at the time of diagnosis are described. Six are alive, having undergone spontaneous maturation/regression; the seventh child died of intestinal obstruction but the pelvis was free of tumour. The better prognosis is considered to be due to the young age at the time of presentation and the site of the tumour.
Case Details
Clinical Characteristics
The diagnosis is quite readily made in some instances, while in others it may present insurmountable difficulties. Plans for treatment require considerations regarding the site, or in metastatic cases sites, the operability of the tumor, and the use of pre- or postoperative irradiation and chemotherapy. The method of management must often be altered by the problems encountered in the individual case.
Remission Characteristics
There is now a larger number of survivors and metastatic disease does not always indicate a fatal prognosis. Recognition of the not infrequent bizarre clinical course, at times resulting in even ‘spontaneous’ arrest, makes caution in the appraisal of therapeutic successes mandatory.
Treatment & Mechanisms
Proposed Remission Mechanisms
Not discussed
Clinical Treatment
The use of pre- or postoperative irradiation and chemotherapy.
Additional Notes
The frequency with which childhood cancers are observed increases annually. In the experience of the Pediatric Department of Memorial Hospital for Cancer and Allied Diseases neuroblastoma is foremost in incidence among the solid malignant tumors that occur in children. This review of 236 cases emphasizes features of clinical significance in diagnosis, therapy, and prognosis.