Spontaneous Regression of Malignant Melanoma | Spontaneous Remission Database

Abstract

Spontaneous regression of a massive recurrence of malignant melanoma in the neck is reported. The patient has survived over six years since regression without evidence of disease. Spontaneous regression is a rare example of host resistance to cancer. Twelve adequately documented instances of spontaneous regression of malignant melanoma have been previously reported. Factors which may contribute to or initiate regression are discussed.

Case Details

Personal Characteristics

46-year-old white man

Clinical Characteristics

A firm, subcutaneous, 8 millimeter nontender, bluish nodule on the antitragus of the right ear. A firm, 1 centimeter node palpable in the upper cervical region just beneath the lobe of the ear. A large, grossly infected tumor mass was present, fungating through the skin of the upper cervical region and extending up over the mastoid and on to the right cheek.

Remission Characteristics

Marked scarring in the right upper cervical region at the site formerly occupied by the fungating tumor. Unusual loss of pigmentation of the skin in the scarred areas. No palpably enlarged cervical nodes. No evidence of tumor.

Treatment & Mechanisms

Proposed Remission Mechanisms

Spontaneous regression, possible host resistance to cancer

Clinical Treatment

Subtotal resection of the ear performed in continuity with a parotidectomy and a radical neck dissection. Plastic prosthesis was constructed for his ear.

Non-Clinical Treatment

Applied vaseline and compresses to the area of his tumor. Prayer.

Additional Notes

The patient survived over six years since regression without evidence of disease. He had refused hospitalization multiple times.