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Spontaneous Regression Of Malignant Melanoma

Malleson, N. 1955Melanoma

British Medical Journal 1(1): March 12 1955; 668

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Abstract

A case of a patient who experienced a spontaneous remission of metastases of malignant melanoma is reported. A chest x-ray showed gross enlargement of the right para-tracheal group of lymph nodes. Biopsy of the nodes revealed “a secondary deposit from a malignant melanoma.” No primary site was found. Without treatment the para-tracheal glands gradually decreased in size and were normal six years later.

Case Details

Personal Characteristics

A white south african student aged 22

Clinical Characteristics

An enlarged supraclavicular lymph node, gross enlargement of the right para-tracheal group of lymph nodes, a secondary deposit from a malignant melanoma

Remission Characteristics

Without treatment the para-tracheal glands gradually decreased in size and were normal six years later

Treatment & Mechanisms

Proposed Remission Mechanisms

Not discussed

Additional Notes

The patient was initially misdiagnosed with tuberculous adenitis. The primary site of the melanoma was not found. The patient was allowed to finish his M. A. and then advised to return home. The patient has remained well, has married, and has now a year-old son.