Spontaneous Regression Of Cutaneous Metastases Of Squamous Cell Carcinoma

Abstract

### Learning Point for Clinicians Metastatic cutaneous squamous cell carcinoma has a poor prognosis and spontaneous regression is exceptionally rare. These patients should be managed within a skin cancer multidisciplinary team and informed of all possible management options. A previously healthy 74-year-old lady was referred to our dermatology department with a rash on her right leg for 3 months. Multiple discrete dermal and subcutaneous nodules were distributed circumferentially on the skin between the knee and the ankle on the right leg (Figure 1a). Figure 1. (a) Clinical photography of right leg at presentation showing multiple subcutaneous metastatic deposits. (b) 18F FDG PET-CT images of right leg at presentation demonstrating multiple foci of abnormal increased 18F FDG accumulation. (c) Clinical photography of right leg showing resolution of metastatic deposits 6 months later. (d) 18F FDG PET-CT images of right leg 6 months after presentation demonstrating radiological regression of the lesions. A biopsy of one of these nodules showed intact epidermis with underlying poorly differentiated acantholytic …