Malignant Neoplasms Of The Larynx Carcinoma Of The Larynx; A Case Of Apparent Regression After Inadequate Therapy
Archives of Otolaryngology 91: April 1970; 385-386
View Original Source →Abstract
Multiple pulmonary nodular densities simulating metastatic cancer were discovered in a routine chest roentgenogram of a 30-year-old pregnant woman. Lung biopsy revealed nodules composed of smooth muscle and collagenous tissue containing entrapped glandular elements. The lesions were initially interpreted as multiple pulmonary fibroleiomyomatous hamartomas (MPFLH). During pregnancy and the postpartum period, the pulmonary nodules regressed spontaneously. A review and critical analysis of published cases as well as our own case indicates that multiple pulmonary fibroleiomyomatous hamartomas cannot be distinguished from benign metastasizing leiomyoma (BML) by either clinical, roentgenographic, or pathologic criteria and that all represent pulmonary metastases from a primary uterine neoplasm. The spontaneous regression of the pulmonary nodules in the present case as well as the increased risk for development of progressive pulmonary insufficiency in the pre-menopausal patients indicates an apparent hormonal dependence. Total abdominal hysterectomy and bilateral salpingo-oophorectomy appears to be the treatment of choice.
Case Details
Clinical Characteristics
Carcinoma of the larynx was diagnosed histologically in one patient following a stripping procedure of the larynx. This was not considered adequate therapy, but further therapy was refused. There was no evidence of this tumor at laryngoscopy two years later or at autopsy 12 years after the initial tumor was found. This patient developed another unusual finding, a metachronous carcinoma of the lung, which caused his death.
Remission Characteristics
No evidence of this tumor at laryngoscopy two years later or at autopsy 12 years after the initial tumor was found.
Treatment & Mechanisms
Proposed Remission Mechanisms
Not discussed
Clinical Treatment
Stripping procedure of the larynx
Additional Notes
The patient refused further therapy after the initial treatment. The patient developed a metachronous carcinoma of the lung, which caused his death.