Spontaneous Regression Of Cancer

Abstract

Certain criteria for the reporting and acceptance of instances of spontaneous regression of cancer in man are presented and discussed. These criteria include: the presence of macroscopic and microscopic evidence of a malignant neoplasm and/or its spread from site of origin; a period of observation during which macroscopic evidence of malignant neoplasm and/or its spread have disappeared and, if possible, biopsy that confirms the sites of primary or secondary spread have shown no evidence of persistent malignant neoplasm; a record of all treatment during the period of observed regression; roentgenographic evidence alone of pulmonary spread is acceptable only with major reservations and should be accompanied by reports of repeated cytologic study of sputum, and/or bronchial aspirations; the presence of severe infection is also to be recorded. While the possible effect of infection on the course of malignant neoplastic disease is still a moot question, with general opinion that it is of little or no importance, its influence cannot be categorically disregarded. There is abundant laboratory evidence that it may in some instances impair, at least temporarily, the progress of neoplastic disease. The author further suggests that a registry of living patients whose histories are acceptable as examples of spontaneous regression be established.