Spontaneous Regression Of Myxofibrosarcoma Of The Thigh After Open Biopsy
Mizuno, T., Susa, M., Horiuchi, K., Shimazaki, H., Nakanishi, K., & Chiba, K. (2019). Spontaneous Regression of Myxofibrosarcoma of the Thigh after Open Biopsy. Case reports in oncology, 12(2), 364–369. https://doi.org/10.1159/000500504
View Original Source →Abstract
Spontaneous regression of sarcoma is exceedingly rare. A 62-year-old male presented with myxofibrosarcoma of the thigh which regressed after open biopsy. Treatment strategy for this condition is not well-documented in the literature. In this report, we describe the case of a spontaneously regressed myxofibrosarcoma successfully treated by resection where the extent of the tumor was determined from the initial MRI. This case demonstrates that myxofibrosarcoma has the potential to regress spontaneously, and astute awareness of this phenomenon is necessary for appropriate management of this condition.
Case Details
Disease Location
Skin
Personal Characteristics
62-year-old man
Clinical Characteristics
Gradually enlarging mass from one year ago in his right thigh. On physical examination, there was a 10 cm non-tender mass on his anterior thigh. The overlying skin was taut and adherent with slight hotness. MRI revealed an elongated 8.6 × 13.3 × 1.9 cm bland mass. An open biopsy was performed. On histological examination, the lesion was composed of spindle and pleomorphic tumor cells with atypical nuclei admixed with myxoid stroma. On immunohistochemistry, the lesion was positive for vimentin, CD34 and ki67 (21.5%), suggestive of myxofibrosarcoma. Wide resection with skin graft was performed
Remission Characteristics
Repeat MRI 21 days after biopsy showed a significant decrease in size. At the time of the surgery 34 days after the open biopsy, the tumor has regressed even further where it was difficult to palpate the mass.
Treatment & Mechanisms
Proposed Remission Mechanisms
Open biopsy activates host immune response
Clinical Treatment
Open biopsy resection (after remission)