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Spontaneous Regression Of Aggressive Cutaneous Squamous Cell Carcinoma

Brufau-Cochs, M. 2025Squamous cell carcinoma (skin)

Brufau-Cochs, M., Sandoval-Clavijo, A., García-Herrera, A., & Toll-Abelló, A. (2025). Spontaneous regression of aggressive cutaneous squamous cell carcinoma. Indian journal of dermatology, venereology and leprology, 91(3), 386–388. https://doi.org/10.25259/IJDVL_1205_2023

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Case Details

Disease Location

Skin

Personal Characteristics

Male patient in his 90s. History of an atypical fibroxanthoma in the left parieto-occipital area that had been removed 3 years before. 6-year history of an asymptomatic and stable renal mass with a radiological appearance of a clear cell carcinoma.

Clinical Characteristics

Presented with a 3-month history of an asymptomatic, rapidly growing lesion on the left parietal area within a large cancerisation field. Physical examination revealed a 10 cm × 13 cm flesh-coloured tumour with satellite lesions compatible with in-transit metastases in the left temporal region, as well as indurated nodules in the lateral cervical area. A punch biopsy from a satellite lesion of the temporal zone was compatible with the diagnosis of an in-transit metastasis of a well-differentiated cutaneous squamous cell carcinoma (cscc). The patient was treated with radiotherapy after regression.

Remission Characteristics

Over the following 12 weeks, progressive amelioration and complete resolution of the lesion were observed without any treatment being started

Treatment & Mechanisms

Clinical Treatment

Biopsy radiotherapy (after sr)