Spontaneous Regression Of Merkel Cell Carcinoma With Positive Detection Of Merkel Cell Polyomavirus By Pcr And Immunohistochemistry
Bellott, T. R., Luz, F. B., Varella, R. B., & Rochael, M. C. (2023). Spontaneous regression of Merkel cell carcinoma with positive detection of Merkel cell polyomavirus by PCR and immunohistochemistry. Anais brasileiros de dermatologia, 98(2), 259–261. https://doi.org/10.1016/j.abd.2021.04.018
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. Famá F, Cicciú M, Sindoni A, Scarfó P, Pollicino A, Giacobbe G, et al. Prevalence of ectopic breast tissue and tumor: a 20-year single center experience. Clin Breast Cancer. 2016;16:e107--12. . Hallam S, Aggarwal A, Predolac D, Cunnick G, Ashford R. Primary ectopic breast carcinoma in a supernumerary breast arising in the anterior chest wall: a case report and review of the literature. J Surg Case Rep. 2013;2013:rjt107. . Zhang S, Yu Y-H, Qu W, Zhang Y, Li J. Diagnosis and treatment of accessory breast cancer in 11 patients. Oncol Lett. 2015;10:1783--8. . Thasanabanchong P, Vongsaisuwon M. Unexpected presentation of accessory breast cancer presenting as a subcutaneous mass at costal ridge: a case report. J Med Case Rep. 2020;14:45. . Visconti G, Eltahir Y, van Ginkel RJ, Bart J, Werker PM. Approach and management of primary ectopic breast carcinoma in the Ariane Sponchiado Assoni a,∗, Beatriz Baptista Abreu da Silva a, Aline Sponchiado Assoni b, Felipe Mauricio Soeiro Sampaio a
Case Details
Disease Location
Skin
Personal Characteristics
76-year-old patient
Clinical Characteristics
Reported fast-growing nodules on the leg, with eight weeks of evolution. The physical examination showed a firm, erythematous, semispherical nodule measuring 4 cm on the left leg, surrounded by similar satellite lesions. Histopathological analysis showed a dermal tumor with extensive proliferation of small basophilic cells, with large, ovoid, hyperchromatic nucleoli and finely dispersed chromatin. Immunohistochemistry was positive for ck20, with a perinuclear, dot-like pattern, and chromogranin a. The diagnosis of merkel cell carcinoma was estbalished. Merkel cell polyomavirus (mcpyv) DNA was detected by pcr and the major viral t-antigen was detected by nuclear positivity in immunohistochemistry. Surgical excision was performed with wide margins. Histopathology of the surgical specimen revealed residual neoplasia circumscribed by connective tissue strands and dermal fibrosis.
Remission Characteristics
These findings regressed considerably three weeks after a shave biopsy of the main lesion was performed
Treatment & Mechanisms
Proposed Remission Mechanisms
Activation of the t-cell-mediated immune response after surgical trauma,
Clinical Treatment
Biopsy surgical excision
Non-Clinical Treatment
None reported