Translocation Of Subcutaneous Lesions To The Skin Surface During Spontaneous Remission In A Case With Systemic Xanthogranuloma With Multiple Visceral Lesions At Birth
Kaisho, J., Dainichi, T., Tahara, J., Kaku, Y., Umeda, K. and Kabashima, K. (2020). Translocation of Subcutaneous Lesions to the Skin Surface During Spontaneous Remission in a Case With Systemic Xanthogranuloma With Multiple Visceral Lesions at Birth. European Journal of Dermatology, . 30(3), 307-308. https://doi.org/10.1684/ejd.2020.3787.
View Original Source →Abstract
1. Kasabach H, Merritt K. Capillary hemangioma with extensive purpura: report of a case. JAMA Pediatr 1940; 59: 1063-70. 2. Grellety T, Italiano A. Angiosarcoma associated with a KasabachMerritt syndrome: report of two cases treated with paclitaxel. Future Oncol 2013; 9: 1397-9. 3. Nagao K, Suzuki K, Yasuda T, et al. Cutaneous angiosarcoma of the buttock complicated by severe thrombocytopenia: a case report. Mol Clin Oncol 2013; 1: 903-7. 4. Massarweh S, Munis A, Karabakhtsian R, Romond E, Moss J. Metastatic angiosarcoma and kasabach-merritt syndrome. Rare Tum 2014; 6: 77-8. 5. Read WL, Williams F. Metastatic angiosarcoma with KasabachMerritt syndrome responsive to gemcitabine and vinorelbine after failure of liposomal doxorubicin and paclitaxel: a case report. Case Rep Oncol 2016; 9: 177-81. 6. Wen S, Zhang W, Yang Y, Sun J. Angiosarcoma of the scalp and face associated with Kasabach-Merritt syndrome and disseminated intravascular coagulation. Indian J Dermatol Venereol Leprol 2016; 82: 96-7. 7. Arcomano MA, Shulkin BL, Petry NA, Wahl RL. Metastatic angiosarcoma with thrombocytopenia and intratumoral indium-111platelet deposition. J Nucl Med 1991; 32: 2278-80. 8. Satoh T, Takahashi Y, Yokozeki H, Katayama I, Nishioka K. Cutaneous angiosarcoma with thrombocytopenia. J Am Acad Dermatol 1999; 40: 872-6. 9. Imafuku S, Hosokawa C, Moroi Y, Furue M. Kasabach-Merritt syndrome associated with angiosarcoma of the scalp successfully treated with chemoradiotherapy. Acta DermVenereol 2008; 88: 193-4. 10. O’Rafferty C, O’Regan GM, Irvine AD, Smith OP. Recent advances in the pathobiology and management of Kasabach-Merritt phenomenon. Br J Haematol 2015; 171: 38-51.
Case Details
Disease Location
Skin
Personal Characteristics
Newborn boy
Clinical Characteristics
Referred with subcutaneous nodules. There were multiple subcutaneous nodules, 5-10 mm in diameter, on the trunk and extremities. Only a few intradermal nodules were detected on the skin surface. A biopsy specimen obtained from a lesion on the right hand revealed an intradermal nodule composed of epithelioid cells and touton giant cells. Computed tomography (CT) revealed multiple nodules in the liver, spleen, lung, and subcutaneous tissues. Therefore, the patient was diagnosed with systemic xanthogranuloma.
Remission Characteristics
Subcutaneous nodules reduced in size and became undetectable, and some of them tended to turn into dermal nodules which appeared at the body surface and then disappeared. CT at eight months demonstrated that most visceral lesions were undetectable
Treatment & Mechanisms
Clinical Treatment
Biopsy