Spontaneous Regression Of Papular Acantholytic Dyskeratosis Of Genitocrural Area: A Case Report With Positive Dif Findings
Jiang, X., & Zhu, T. (2020). Spontaneous Regression of Papular Acantholytic Dyskeratosis of Genitocrural Area: A Case Report with Positive DIF Findings. Indian journal of dermatology, 65(5), 437–438. https://doi.org/10.4103/ijd.IJD_30_19
View Original Source →Abstract
A warm, moist, high friction environment is recognized as a predisposing factor of PAD of genitocrural area, while the pathogenesis is still uncertain.[3] Somatic ATP2C1 (ATPase gene associated with Hailey-Hailey disease) and ATP2A2 (ATPase gene associated with Darier’s disease) mutations in skin lesions of PAD of genitocrural area were identified.[3] Some reports of positive DIF of intercellular IgG and C3 within the epidermis and premenstrual itching and burning of a female patient suggested that immune dysfunction and ovarian hormones might participate in the pathogenesis of this condition.[3,5] The treatment of PAD of genitocrural area is challenging. Topical potent steroid, pimecrolimus 1%, tacrolimus 0.1%, maxacalcitol and oral viaminate, acitretin had been used to treat this disease, and results were variable. For those patients with limited skin lesions, surgery might be a good choice.[3,5]
Case Details
Disease Location
Skin
Personal Characteristics
22-year-old chinese woman WHO was 2-month postpartum
Clinical Characteristics
Presented for slightly pruritic eruptions on her perianal area for 5 months. Cutaneous examination showed multiple smooth, grey-whitish, firm, dome-shaped papules of 2–5 mm in diameter on perianal area, and part of them coalesced into verrucous plaques. Skin biopsy revealed acantholytic dyskeratosis with suprabasal cleft formation and villi, corps ronds and grains were detected in epidermis, and a superficial perivascular lymphocytic infiltration was displayed in the underlying dermis. The diagnosis of papular acantholytic dermatosis (pad) of genitocrural area was made.
Remission Characteristics
Two weeks later, most of the skin lesions regressed, and 2 months later, the patient just presented scattered papules over the perianal area