Spontaneous Regression Of Palmar Warts After Suffering From Diffuse Contact Dermatitis Against Alkyl Bromide
Egawa, G., Honda, T., & Kabashima, K. (2021). Spontaneous Regression of Palmar Warts after Suffering from Diffuse Contact Dermatitis against Alkyl Bromide. Case reports in dermatology, 13(1), 54–57. https://doi.org/10.1159/000511998
View Original Source →Abstract
Contact immunotherapy with several sensitizing chemicals such as diphenylcyclopropenone (DPCP) or squaric acid dibutyl ester (SADBE) have been used for the treatment of recalcitrant or multiple warts. Here, we report a case of multiple verrucae vulgaris (VV) on the palm which spontaneously resolved after the development of systemic contact dermatitis against alkyl bromide. We considered that our case accidentally mimics contact immunotherapy against multiple VV. VV sometimes regress spontaneously, which may be triggered by accidental contact dermatitis, as shown in our case.
Case Details
Disease Location
Skin
Personal Characteristics
25-year-old japanese man
Clinical Characteristics
Complaining of rashes on the right thigh. He had been engaged in chemical experiments, and 12 days before the visit, he had spilled alkyl bromide on his right thigh. On day 1–2, erythema with tiny vesicles had appeared on the thigh, and on around day 7, he had complained of fever and vomiting, and the erythema had spread over the trunk.. At the moment of evaluation (day 12 after the spill) the erythema on the trunk had disappeared. It was noticed that several warts on his left palm, which he had suffered from for years in spite of multiple cryotherapies, had turned brownish. Histological analysis of the right thigh revealed massive infiltration of lymphocytes and vacuolar changes of the epidermis. He was diagnosed with contact dermatitis with systemic symptoms and prescribed a topical steroid (clobetasol propionate) ointment.
Remission Characteristics
The rashes on the thighs had disappeared by the visit on day 21, and by his next visit on day 50, all the vv on the palm had resolved
Treatment & Mechanisms
Proposed Remission Mechanisms
Verruca vulgaris on his palm had spontaneously regressed due to an immunological mechanism.
Clinical Treatment
Biopsy topical clobetasol propionate
Non-Clinical Treatment
None reported