Disappearing Nodules: Spontaneously Regressing Pulmonary Amyloidosis
Glass, L. N., Sumon, M., Goulart, H., & Ahari, J. (2019). Disappearing nodules: spontaneously regressing pulmonary amyloidosis. BMJ case reports, 12(5), e229718. https://doi.org/10.1136/bcr-2019-229718
View Original Source →Abstract
A case report of spontaneous regression of pulmonary amyloidosis, diffuse interstitial pattern, in an elderly patient.
Case Details
Disease Location
Lung, lymph nodes
Personal Characteristics
82-year-old woman. History of hypothyroidism, left breast cancer with mastectomy, hypertension, hyperlipidemia, diet-controlled diabetes and gastro-oesophageal reflux disease
Clinical Characteristics
She tripped over a loose brick and suffered a mechanical fall with injury to her left knee. She noticed left-sided chest pain 1 day later without radiation. CT scan demonstrated septal thickening, mediastinal lymphadenopathy, hilar lymphadenopathy, calcified hilar lymph nodes, right hilar hypodensity and innumerable 2–3 mm pulmonary nodules. Transbronchial biopsy of the right upper lobe showed thickened vascular walls and a deposit of amorphous material around the bronchiole. Serum immunofixation identified IGA light chain monoclonal gammopathy. Bone marrow biopsy revealed hypercellular marrow and trilineage haematopoiesis with 5%–10% plasma cells and no evidence of frank myeloma.
Remission Characteristics
On repeat CT imaging 6 months later, a decrease in parenchymal disease was noted
Treatment & Mechanisms
Clinical Treatment
Biopsy