A Very Rare Case Of Spontaneous Regression Of Basaloid Squamous Cell Carcinoma Of The Lung
Koike, S., Shiina, T., Takasuna, K., Kato, A., Atagi, T., & Nakamura, T. (2024). A very rare case of spontaneous regression of basaloid squamous cell carcinoma of the lung. Thoracic cancer, 15(6), 500–502. https://doi.org/10.1111/1759-7714.15217
View Original Source →Abstract
Spontaneous regression of non-small cell lung cancer is relatively rare. Here, we present a very rare case of spontaneous regression of lung cancer which occurred in a patient with basaloid squamous cell lung cancer. To the best of our knowledge, this is the first report of such a case. A 76-year old man was referred to our hospital with nodules in the right upper lobe determined by chest computed tomography. The nodules spontaneously regressed during follow-up. Two years later, the tumor had regrown and the patient subsequently underwent surgery. The pathological findings showed basaloid squamous cell carcinoma. Stimulation of the immune system was considered to be the cause of the spontaneous regression and CD-8 positive and CD-4 positive lymphocytes might play an important role.
Case Details
Disease Location
Lung, lymph nodes
Personal Characteristics
76-year-old man, history of prostate cancer
Clinical Characteristics
Referred with nodules in the right upper lobe of the lung on chest computed tomography (CT), smoking history of 20 pack-years. CT revealed a 10.5 x 9.7 mm nodule at the peripheral part of b2b, close to v3aii, and a 7.8 x 5.4 mm nodule in s2 located in the right upper lobe. Two years later, that patient was again referred with a nodule in the right upper lobe of the lung. CT revealed a 19.3 x 10.4 mm nodule at the peripheral part of b2b in exactly the same place as the larger nodule revealed 2 years previously, close to v3aii. Transbronchial fine needle aspiration the tumor was diagnosed as squamous cell carcinoma. Right upper lobectomy and nd2a-1 lymph node dissection was performed.
Remission Characteristics
4 months after the first visit, when both nodules had shrunk to an almost unrecognizable size. Pathological examination of the excised lung lobe revealed sheets of hyperchromatic basaloid cells with minimal cytoplasm and peripheral palisading with alveolar structure. Widespread necrosis was seen inside the tumor
Treatment & Mechanisms
Proposed Remission Mechanisms
Stimulation of the immune system is considered to be the cause of the sr
Clinical Treatment
Right upper lobectomy and nd2a-1 lymph node dissection