Lymphoma - Spontaneous Remission Database

Lymphoma

Epidemiology

Lymphoma ranks among the most significant hematological malignancies worldwide, with an estimated global incidence of approximately 605,000 cases reported annually in 2020.¹ In the United States, the annual incidence of lymphoma is estimated to be about 89,010 new cases, with approximately 21,080 deaths each year, highlighting the substantial public health impact of this disease.² Despite advances in therapies, lymphoma remains a significant contributor to cancer-related mortality across regions.³ The occurrence of spontaneous remission (SR) in lymphoma is remarkably rare, with documented rates often below 2%, and the true incidence may be further obscured due to underreporting and lack of recognition of remissions that are less pronounced.⁴

Clinical Characteristics:

A total of 205 well-documented cases of spontaneous remission (SR) in lymphoma have been reported between 1956 and 2025. The ages of affected individuals ranged from 2 to 94 years (mean ≈ 52.2 years), with a near-equal male-to-female ratio of approximately 1.1:1 and a peak incidence observed in the 60–80-year age group. Overall, SR was documented across a wide age spectrum but occurred more frequently in older adults, with remission most often noted in generalized or disseminated disease rather than localized lesions, involving both nodal and extranodal sites. See table 1 below for further information.

Histological Characteristics:

Patients who experienced spontaneous remission of lymphoma typically presented with lymphadenopathy or extranodal masses confirmed histologically as malignant lymphoid proliferations. Most cases involved advanced or systemic disease, with the lymph nodes, spleen, and bone marrow as the predominant primary sites, and occasional involvement of the skin, gastrointestinal tract, central nervous system, or thyroid. Remission was verified by follow-up biopsies or imaging demonstrating regression or disappearance of lymphoma cells. Nearly all SR cases showed durable clinical stability or long-term remission, far exceeding the expected prognosis for untreated lymphoma.

Proposed Contributing Mechanisms:

Several mechanisms have been proposed to explain spontaneous remission in lymphoma. The most common involve immune activation following bacterial or viral infections, febrile illnesses, or other inflammatory events. Additional contributing factors include biopsy-related immune stimulation, recovery after withdrawal of immunosuppressive or cytotoxic therapy such as methotrexate or cyclosporine, and immune restoration following discontinuation of antiretroviral or other immunomodulatory treatments. A minority of reports suggest cellular processes such as apoptosis, cytokine-mediated tumor inhibition, or radiation-related immune enhancement as potential contributors.

Site and Extent of Remission:

In most reported cases of spontaneous remission in lymphoma, regression occurred within nodal sites, including cervical, axillary, mediastinal, and abdominal lymph nodes. Extranodal remissions were also documented, involving the skin, gastrointestinal tract, central nervous system, thyroid, breast, and other organs. In many patients, remission extended across multiple regions, reflecting systemic disease resolution rather than localized tumor regression. The duration of remission ranged from a few weeks to more than 20 years, with a considerable number of patients maintaining prolonged clinical and radiologic remission in the absence of active treatment.

Table 1: Leukemia SR Cases and Clinical Characteristics

Author–year	Age/sex	Primary site	Remission site	Proposed mechanisms	Follow-up
Anday et al., 1956¹	68/M	Lymph nodes and liver	Lymph nodes and liver	Humoral factors	4 years
Diwani et al., 1960²	2.5/M	Neck	Neck lymph nodes	Not reported	Not reported
Tigerightt et al., 1962³	43/M	Mediastinal and axillary nodes	Paratracheal nodes and skin	Infection-related immune response	Not reported
Tigerightt et al., 1962³	56/F	Submandibular and cervical nodes	Axillary node	Infection-related immune response	Not reported
Kwittken et al., 1966⁴	83/F	Scalp	Scalp	Not reported	15 months
Burkitt & Kyalwazi, 1967⁵	9/M	Jaw	Jaw	Not reported	Not reported
Burkitt & Kyalwazi, 1967⁵	6/M	Mandible and maxilla	Mandible and maxilla	Not reported	14 months
Burkitt & Kyalwazi, 1967⁵	36/F	Breast and shoulder	Breast and shoulder	Not reported	Not reported
Burkitt & Kyalwazi, 1967⁵	4/F	Maxilla and orbit	Maxilla and orbit	Infection-related immune response	2 years
Burkitt, 1967⁶	Not reported	Blood	Blood, bone marrow	Immunological response	Not reported
David & Burkitt, 1968⁷	9/M	Maxilla, orbit, intracranial	Maxilla and orbit	Immunological response	2 months
David & Burkitt, 1968⁷	11/M	Maxilla	Maxilla	Immunological response	7 years
David & Burkitt, 1968⁷	6/F	Maxilla and abdomen	Not reported	Not reported	3 months
David & Burkitt, 1968⁷	7/F	Maxilla and abdomen	Not reported	Not reported	3 months
David & Burkitt, 1968⁷	15/M	Maxilla and orbit	Maxilla and orbit	Immunological response	3 years
David & Burkitt, 1968⁷	9/M	Maxilla, orbit, intracranial	Maxilla and orbit	Immunological response	10 months
David & Burkitt, 1968⁷	9/M	Maxilla	Maxilla	Immunological response	Not reported
David & Burkitt, 1968⁷	6/M	Maxilla and abdomen	Maxilla and abdomen	Immunological response	2 years
Kiely & Harrison, 1970⁸	16/M	Inguinal node	Inguinal and mediastinal nodes	Immunologic factors	5 years
Jamra et al., 1970⁹	12/F	Face, iliac fossa, ovary	Face and ovaries	Not reported	3 months
Bluming & Ziegler, 1971¹⁰	8/M	Orbit	Orbit	Infection-related immune response	4 months
Ziegler, 1976¹¹	Not reported	Blood	Blood	Antitumor immunity	Not reported
Gattiker et al., 1980¹²	Not reported	Not reported	Not reported	Not reported	several years
Krikorian et al., 1980¹³	42/M	Lymph nodes	Lymph nodes	Not reported	5 years
Krikorian et al., 1980¹³	43/F	Nodes	Peripheral and thoracic nodes	Not reported	32 months
Krikorian et al., 1980¹³	68/F	Nodes	Peripheral and abdominal nodes	Not reported	2 years
Krikorian et al., 1980¹³	42/M	Nodes	Peripheral and abdominal nodes	Not reported	5 years
Weingarten et al., 1983¹⁴	61/M	Intracerebral	Intracerebral	Steroid effect	5 months
Weingarten et al., 1983¹⁴	60/F	Intracerebral	Left temporal lobe	Steroid effect	4 years
Weingarten et al., 1983¹⁴	69/F	Intracerebral	Intracerebral	Not reported	3 months
Weingarten et al., 1983¹⁴	69/F	Frontal lobe	Frontal lobe	Not reported	4 months
Horning et al., 1984¹⁵	Not reported	Not reported	Lymph nodes	Viral infection, interferon effect	5–10 years
McClain et al., 1985¹⁶	12/F	Gastrointestinal tract, reproductive organs, CNS	Bone marrow	Infection-related immune response	11 months
Weaver et al., 1985¹⁷	69/F	Mediastinum	Mediastinum	Hormonal factors	27 days
Grem et al., 1986¹⁸	54/F	Tongue base	Cervical node	Infection-related immune response	4 years
Rubin et al., 1987¹⁹	56/F	CNS	CNS	Steroid-induced cytotoxicity	Not reported
Strauchen et al., 1987²⁰	84/M	GI (stomach, antrum)	Stomach	Immunomodulatory effect	10 months
Strauchen et al., 1987²⁰	73/M	GI (stomach, antrum)	Gastric antrum	Immunomodulatory effect	16 months
Poppema et al., 1988²¹	12/M	Tonsil and cervical node	Tonsil and cervical node	Host cytotoxic response	3 years
Sugita et al., 1988²²	63/F	CNS	Frontal and parietal lobes	Immune response	Not reported
Shigematsu et al., 1989²³	40/F	Stomach (pyloric antrum)	Stomach	Not reported	69 months
Shigematsu et al., 1989²³	73/M	Stomach (posterior antrum)	Stomach	Not reported	44 months
Wolf, 1989²⁴	56/F	Axilla and groin nodes	Epitrochlear and inguinal nodes	Infection-related immune response	>20 years
Drobyski et al., 1989²⁵	Not reported	Not reported	Not reported	Immune response, infection	Not reported
Fric et al., 1990²⁶	21/M	Brain	Brain	Immunosuppression withdrawal	Not reported
Aelbrecht & Geerights, 1990²⁷	75/F	Skin	Cutaneous lesions	Not reported	10 months
Mayou et al., 1991²⁸	43/F	Skin	Cutaneous nodules	Not reported	6 months
Daniels et al., 1992²⁹	43/M	Pharynx	Cervical nodes	Infection-related immune response	Infection-related immune response
Karnad et al., 1992³⁰	30/M	Skin and chest wall	Forehead and chest wall tumors	Immune response, interferon activity	Not reported
Terriff et al., 1992³¹	34/M	Central nervous system	Thalamus and midbrain lesion	Tumor necrosis	Not reported
Grigg et al., 1992³²	67/M	Lymph nodes	Bone marrow and lymph nodes	Viral infection, immune response	16 months
Motley et al., 1992³³	27/F	Skin	Skin	Infection-related immune response	Not reported
Kiyohara et al., 2000³⁴	62/F	Intravascular (skin and bone marrow)	Skin and bone marrow	Not reported	Not reported
Ranheim et al., 2000³⁵	35/M	Oral cavity, lung, bowel, spleen	Oral cavity, lung, bowel, spleen	Not reported	9 years
Takezako et al., 2000³⁶	79/F	Lymph nodes	Lymph nodes (inguinal, para-aortic)	Infection-induced immune response	18 months
Takenaka et al., 2000³⁷	76/M	Rectum	Rectum	Not reported	19 months
Phanish et al., 2002³⁸	52/F	Spleen	Spleen	Not reported	14 months
Baird et al., 2002³⁹	69/F	Cervical lymph nodes	Cervical lymph nodes	Methotrexate withdrawal	14 months
Ohgi et al., 2002⁴⁰	61/F	Lumbar spine	Lumbar spine	Not reported	8 months
Mangel et al., 2003⁴¹	47/M	Mediastinum (lymph nodes)	Mediastinum, and axillary lymph nodes	Not reported	15 months
Koga et al., 2003⁴²	78/F	Gingiva (left maxillary)	Gingiva (left maxillary)	Immune response	36 months
Kon et al., 2003⁴³	61/M	CNS (corpus callosum, tectum)	Corpus callosum	Not reported	3.5 years
Ogata et al., 2004⁴⁴	70/M	Stomach	Stomach	Withdrawal of cyclosporine treatment	10 months
Heibel et al., 2004⁴⁵	70/M	Oral cavity (mandible)	Oral cavity (mandible)	Biopsy-induced apoptosis	20 months
Iihara et al., 2004⁴⁶	46/F	Breast (right)	Breast (right)	Biopsy-induced immune response	7 years
Chang et al., 2004⁴⁷	40/F	Conjunctiva	Conjunctiva and orbit	Biopsy-induced immune activation	5 weeks
Kumar et al., 2004⁴⁸	45/M	Left axillary lymph nodes	Left axillary, mediastinal, and para-aortic lymph nodes	Not reported	6 months
Kumar et al., 2004⁴⁸	59/F	Left parotid lymph node	Inguinal lymph nodes	Not reported	5 years
Kumar et al., 2004⁴⁸	75/M	Posterior cervical lymph nodes (left neck)	Cervical lymph nodes	Not reported	14 months
Ugurlu & Bartley, 2004⁴⁹	76/M	Orbital apex	Orbital apex, frontal lobe	Not reported	2 years
Thonhofer et al., 2005⁵⁰	64/F	Sinuses	Sinuses	Methotrexate withdrawal	6 months
Futagami et al., 2005⁵¹	36/M	Subcutaneous tissue (left thigh)	Subcutaneous tissue (left thigh)	Biopsy-induced immune response	6 months
Parekh et al., 2005⁵²	47/M	Cecum	Cecum	Antiretroviral therapy for HIV	5.5 years
Kamiya et al., 2006⁵³	72/M	Skin (left forearm)	Skin (left forearm)	Not reported	1 year
Kamiya et al., 2006⁵³	32/F	Skin (right cheek)	Skin (right cheek)	Not reported	2 years
Sakuma et al., 2006⁵⁴	70/F	Intraoral mucosa	Hard palate	Post-biopsy immune activation	38 months
Svensson et al., 2006⁵⁵	48/F	Bone marrow	Abdominal lymph nodes, bone marrow	Methotrexate withdrawal	12 months
Partap & Spence, 2006⁵⁶	45/M	CNS	CNS	Immune response	18 months
Matsuo et al., 2007⁵⁷	72/M	Bilateral conjunctiva	Bilateral conjunctiva	Not reported	24 months
Patel et al., 2007⁵⁸	35/F	Left axilla	Left axilla	Not reported	2 years
Shimada et al., 2007⁵⁹	54/F	Lungs	Lungs, liver, spleen	Methotrexate withdrawal	3 months
Armstrong et al., 2007⁶⁰	35/M	Oral cavity	Oral cavity	HAART-induced immune restoration	1 month
Abe et al., 2007⁶¹	89/M	Inguinal lymph node	Inguinal and cervical lymph nodes	Immune modulation	31 months
Rujirojindakul et al., 2007⁶²	26/M	Submandibular gland	Lymph nodes	Immune response	6 months
Mohsin et al., 2007⁶³	48/M	Skin (anterior chest wall and back)	Skin (anterior chest wall and back)	Not reported	24 months
Daly et al., 2008⁶⁴	56/M	Oral cavity	Oral cavity	Biopsy-induced immune activation	4 years
McCabe et al., 2008⁶⁵	2/M	Right mastoid	Right mastoid	Not reported	24 months
Isobe et al., 2009⁶⁶	65/F	Skin (eyelid)	Submandibular lymph node	EBV-related immune activation	5 years
Chiu et al., 2009⁶⁷	64/M	Skin (right leg)	Skin (right leg)	Reduction of immunosuppression	9 months
Engel & Lee, 2009⁶⁸	Elderly/M	Cervical lymph nodes	Cervical, axillary, and tonsillar regions	Trauma-related immune activation	4 weeks
Makino et al., 2010⁶⁹	38/M	Ileum mucosa	Ileum mucosa	Not reported	24 months
Rampisela & Donner, 2010⁷⁰	14/M	Lymph nodes	Lymph nodes	Not reported	4 years
Iwatani et al., 2011⁷¹	69/F	Breast	Breast	Biopsy-induced immune response	Not reported
Norimura et al., 2011⁷²	59/F	Duodenum	Duodenum	Not reported	3-4 months
Norimura et al., 2011⁷²	76/F	Duodenum	Duodenum	Not reported	Not reported
Norimura et al., 2011⁷²	76/M	Duodenum	Duodenum	Not reported	Not reported
Norimura et al., 2011⁷²	72/M	Duodenum	Duodenum	Not reported	7 months
Norimura et al., 2011⁷²	67/F	Duodenum	Duodenum	Not reported	7 months
Norimura et al., 2011⁷²	72/F	Duodenum	Duodenum	Not reported	Not reported
Gencoglan et al., 2011⁷³	48/F	Skin (left forearm)	Skin (left forearm)	Biopsy-induced apoptosis	10 months
Cassaday et al., 2011⁷⁴	54/F	Intra-abdominal lymph nodes	Liver, spleen, and intra-abdominal lymph nodes	Withdrawal of adalimumab	3 months
Kameda et al., 2012⁷⁵	12/F	Cervical lymph nodes	Cervical lymph nodes, skin	Not reported	4 weeks
Kase et al., 2012⁷⁶	80/M	Eye	Intraocular tissues	Immune response, CD8 T cells	8 months
Buckner et al., 2012⁷⁷	67/F	Maxillary sinus	Maxillary sinus	Infection-induced immunity	1 year
Mohsen et al., 2012⁷⁸	86/F	Lymph nodes	Lymph nodes	Immune response	8 months
Biswas & Tan, 2012⁷⁹	8/F	Skin	Left areola	Apoptosis	6 years
Zhang et al., 2013⁸⁰	24/F	Central nervous system and lungs	Brain and lung lesions	Improved immunity	1 year
Udupa et al., 2013⁸¹	10/F	Lymph nodes	Lymph nodes, bone marrow, liver	Immune response	14 months
Mizuno et al., 2013⁸²	94/F	Lymph nodes	Lymph nodes	Immune recovery	10 months
Humeniuk et al., 2014⁸³	63/M	Lymph nodes	Lymph nodes	Not reported	12 months
Sekiguchi et al., 2014⁸⁴	68/F	Left breast	Left breast	Not reported	14 months
Rojas-Hernandez et al., 2014⁸⁵	57/M	Stomach	Gastric	Not reported	2 years
Kang et al., 2015⁸⁶	57/F	Lung	Lung	Apoptosis of lymphocytes	3 months
Kaibuchi et al., 2015⁸⁷	87/M	Gingiva	Gingiva	Biopsy-induced immune stimulation	2.5 years
Birendra et al., 2015⁸⁸	55/M	Kidney	Kidney	Immune reconstitution	10 months
Bekoz et al., 2015⁸⁹	38/M	Lymph nodes	Axillary lymph nodes	Biopsy-induced trauma	Not reported
Igawa et al., 2015⁹⁰	80/M	Oral cavity	Gingiva	Immune response	5 months
Takahashi et al., 2015⁹¹	61/F	Blood	Bone marrow	Apoptosis	6 years
Kato et al., 2015⁹²	60/F	Lymph nodes	Supraorbital region	Immune response	36 months
Ureshino & Miyahara, 2016⁹³	58/F	Blood	Blood and skin	Immune response	58 months
Ayala et al., 2016⁹⁴	62/M	Skin	Right cheek	Not reported	12 months
Ogihara et al., 2016⁹⁵	66/M	Urinary bladder	Urinary bladder	Recovery from immunosuppression	Not reported
Sasaki et al., 2016⁹⁶	83/F	Thyroid	Thyroid	Radiation exposure	9 years
Sasaki et al., 2016⁹⁶	51/F	Thyroid	Thyroid	Radiation exposure	8 years
Sasaki et al., 2016⁹⁶	60/M	Ileocecal region	Ileocecal region	Radiation exposure	Not reported
Sasaki et al., 2016⁹⁶	69/F	Thyroid	Thyroid	Radiation exposure	21 years
Fukushima et al., 2016⁹⁷	72/F	Lung	Lung	Biopsy-induced immune activation	40 months
Potts et al., 2017⁹⁸	59/M	Lymph nodes	Para-aortic lymph nodes	Biopsy-induced immune response	12 months
Hees et al., 2017⁹⁹	20/M	Skin	Left alar base	Not reported	4 months
Cornish et al., 2017¹⁰⁰	66/M	Lymph nodes	Lymph nodes and spleen	Not reported	52 months
Chan et al., 2017¹⁰¹	74/M	CNS	CNS	Immune response	2 years
Jimura et al., 2017¹⁰²	72/F	Skin	Left arm	Immune response	21 months
Miyagawa et al., 2017¹⁰²	46/M	Skin	Lip	Biopsy-induced immune activation	14 months
Fleming et al., 2018¹⁰³	51/F	Breast	Breast	Not reported	Not reported
Fleming et al., 2018¹⁰³	24/F	Breast	Breast	Not reported	Not reported
Ye et al., 2018¹⁰⁴	48/M	Right inguinal lymph node	Lymph nodes	Immune response	5 years
Ye et al., 2018¹⁰⁴	63/M	Right axillary lymph node	Lymph nodes	Immune response	3 years
Ye et al., 2018¹⁰⁴	68/M	Inguinal and cervical lymph nodes	Lymph nodes	Immune response	5 years
Ye et al., 2018¹⁰⁴	44/F	Inguinal and pelvic lymph nodes	Lymph nodes, Bone marrow	Immune response	1.5 years
Froehlich et al., 2018¹⁰⁵	44/F	Skin	Skin	Drug withdrawal immune restoration	4 weeks
Graham et al., 2018¹⁰⁶	79/M	Skin	Left leg	Immune response	12 months
Ramos et al., 2018¹⁰⁷	50/F	Brain	Brain	Viral infection–induced NK cell activation	Not reported
Toberer et al., 2018¹⁰⁸	66/M	Skin	Left lower leg	Immune response	Not reported
Aiko et al., 2018¹⁰⁹	79/M	Lung	Lung	MTX withdrawal immune recovery	1 month
Swoboda et al., 2018¹¹⁰	66/M	Skin	Skin	Not reported	Few months
Pasvolsky et al., 2019¹¹¹	32/F	Lymph nodes	Lymph nodes	Not reported	2 years
Snijder et al., 2019¹¹²	88/F	Lymph nodes	Lymph nodes	Biopsy-induced immune response	3 months
Tanaka et al., 2019¹¹³	35/M	Small intestine	Small intestine, Lymph nodes	PD-L1/PD-1–mediated apoptosis	3 months
Yordanova et al., 2019¹¹⁴	69/M	Bone marrow	Bone marrow, Spleen	Not reported	6 weeks
Hosoda et al., 2019¹¹⁵	70/M	Bronchi	Bronchi	Not reported	Not reported
Morigi et al., 2019¹¹⁶	47/M	Lymph nodes	Lymph nodes, Bone marrow, Spleen, Stomach	Immune response	3 months
Nakamoto et al., 2020¹¹⁷	74/M	Liver	Liver, Spleen, Bone	Immune-mediated response	1.5 months
Tang et al., 2020¹¹⁸	78/M	Skin	Skin	Not reported	8 months
Fleming et al., 2020¹¹⁹	24/F	Breast	Breast	Not reported	Not reported
Fleming et al., 2020¹¹⁹	51/F	Breast	Breast	Not reported	2 months
Stanoszek et al., 2021¹²⁰	35/M	Retroperitoneum	Retroperitoneum	Biopsy-induced immune response	6 months
Furukawa et al., 2021¹²¹	76/F	Vagina	Vagina, Lung	Not reported	1 year
Gambichler et al., 2021¹²²	57/M	Lymph nodes	Lymph nodes	Vaccine-induced immune activation	1 month
Desana et al., 2021¹²³	54/F	Cervix	Cervix	Biopsy-induced immune response	Not reported
Peeters et al., 2021¹²⁴	59/M	Cheek	Cheek	T-cell–mediated immunity	5.5 months
Gong et al., 2021¹²⁵	65/F	Vitreous	Vitreous	Not reported	1 week
Sherkat et al., 2022¹²⁶	11/F	Lymph nodes	Lymph nodes, Spleen	Infection-related immune activation	Several months
Aoki et al., 2022¹²⁷	84/M	Gingiva	Gingiva	Drug withdrawal effect	Not reported
Lee et al., 2022¹²⁸	61/M	Sinus	Sinus	Biopsy-induced immune response	Not reported
Ogawa et al., 2022¹²⁹	63/F	Breast	Breast, lung, retroperitoneum	Methotrexate withdrawal	6 months
Kongwattananon et al., 2022¹³⁰	80/M	Eye	Eye	Not reported	1 year
Gan et al., 2023¹³¹	71/F	Eye	Eye	Biopsy-induced immune response	6 months
Hayashino et al., 2023¹³²	55/F	Pleura, Pericardium	Pleura, Pericardium	Not reported	Not reported
Li et al., 2023¹³³	62/M	Skin	Skin	Biopsy-induced immune response	3 months
Aizawa et al., 2023¹³⁴	15/M	Maxillary bone	Maxillary bone	Not reported	8 months
Abla et al., 2023¹³⁵	3/M	Lymph nodes	Lymph nodes	Not reported	3 weeks
Khaw et al., 2024¹³⁶	32/M	Colon	Brain, Colon	Immune reconstitution	1 year
Winkler et al., 2024¹³⁷	53/F	Skin	Skin	Reactive T-cell infiltration	9 years
Tomai et al., 2024¹³⁸	27/F	Mediastinum	Mediastinum, Lymph nodes	Feto-maternal microchimerism	6 months
Goto et al., 2024¹³⁹	75/F	Mandible	Mandible, Lungs	MTX withdrawal immune recovery	6 months
Teoh et al., 2025¹⁴⁰	35/M	Skin	Skin	Immune reconstitution	3 months
Li et al., 2025¹⁴¹	72/M	Lung	Lung	Biopsy-induced immune response	5 months
Moreno et al., 1991¹⁴²	79/M	Forehead and anterior scalp			2 months
Moreno et al., 1991¹⁴²	83/M	Face, neck, trunk			6 months
Weintraub, 1969¹⁴³	68/M	Axillary and inguinal regions	Spleen and liver	Interferon production	4 weeks
Buchi et al., 1983¹⁴⁴	76/F	Lymph nodes	Lymph nodes	Immune reaction	Lymphadenopathies disappeared by April 1980
Buchi et al., 1983¹⁴⁴	76/F		Lymph nodes	T lymphocyte subset imbalance
Kwittkin & Goldberg et al., 1966¹⁴⁵	83/F	Scalp	Scalp	Local trauma considered	8 months
Kirikorian et al., 1980¹⁴⁶	42/M	Lymph nodes	Lymph nodes	Host immunity and environmental factors	Asymptomatic at 5 years
Kirikorian et al., 1980¹⁴⁶	68/F	Lymph nodes	Lymph nodes	Host immunity	Asymptomatic at 2 years
Kirikorian et al., 1980¹⁴⁶	43/F	Lymph nodes	Lymph nodes	Host immunity	32 months
Stevanovic & Majcan et al., 1961¹⁴⁷	26/F	Face, genital area	Forehead tumor, genital tumor	Progressive fibrosis, inflammatory process	Discharged 2 months after admission
Stevanovic & Majcan et al., 1961¹⁴⁷	36/M	Back		Connective tissue alteration
Gurcay, 1969¹⁴⁸	16/M	Mediastinal mass and cervical lymph nodes	Cervical lymph nodes and mediastinal mass	Surgical exploration and procaine role
Monthstanaro & Patton et al., 1976¹⁴⁹	61/F	Spleen		Removal of the spleen	11 years
Williams, 1980¹⁵⁰	46/M	Skin	Skin nodules		2.5 years
Green et al., 1984¹⁵¹	48/F	Lymph nodes			Complete remission until Feb 1981
Green et al., 1984¹⁵¹	42/M	Lymph nodes			Complete remission
Hernandez et al., 2013¹⁵²	65/M	Cerebral, right frontal CC	Cerebral lesions	Immune theory	4 months, asymptomatic
Alcantara-Gozalez et al., 2014¹⁵³	82/F	Skin on right leg	Skin lesions	Infiltrate contributed to regression	4 weeks
Gonzalez et al., 2015¹⁵⁴	44/M	Left nasal ala	Left nasal ala		Asymptomatic after 1 year
Marrero-Aleman et al., 2017¹⁵⁵	83/F	Back of right leg	Back of right leg	Immune response against tumor cells	Asymptomatic after 1 year
Monthszen et al., 2013¹⁵⁶	85/M	Prostate	Pelvic lymph nodes	Immunological response post-biopsy	31 months
Adiquzel et al., 2009¹⁵⁷	89/M	Body cavities	Pleural effusion	None reported	40 months
Blokx et al., 2012¹⁵⁸	65/F	Skin ulcer	Skin ulcer	Antiviral treatment and reduced immunosuppression	18 months
Korner et al., 2011¹⁵⁹	53/M	Brain (CNS)	Deep white matter of right hemisphere	Infarction and necrosis	Symptom free, remarkable tumor reduction
Lelievre, 2005¹⁶⁰	52/M	Lymph nodes and spleen	Lymph nodes	Discontinuation of cyclosporine	30 months, psoriasis controlled
Parekh & Koduri et al., 2003¹⁶¹	46/M	Lymph nodes, spleen, liver	Left axilla		4 weeks post-surgery
Tamas et al., 2011¹⁶²	66/F	Tongue			7 years, untreated
Nishimura, 2021¹⁶³	23/F	Bilateral areolae	Bilateral areolae	Self-limited disease or biopsy-triggered regression	6 months
Takatsu, 2021¹⁶⁴	69/M	Brain	Right deep white matter	Regression and progression of inflammation	7 days
Han & Sokal et al., 1971¹⁶⁵	69/F		Lymph nodes and liver		Normal lymphocyte count reached in September 1966
Getzen, 1967¹⁶⁶	41/F				Spontaneous remission, normal coagulation studies
Houbouyan et al., 1984¹⁶⁷	2/F				Spontaneous and quick recovery
Ziliotto & Miotto et al., 1980¹⁶⁸	80/F		Lymph nodes
Fiorillo et al., 1981¹⁶⁹				Spontaneous remission
Matthews et al., 1988¹⁷⁰				Lymphoid stem cell clone development	18 years

References

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